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proteome profiler human phospho rtk array kit  (R&D Systems)


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    R&D Systems proteome profiler human phospho rtk array kit
    Proteome Profiler Human Phospho Rtk Array Kit, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 358 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phospho-rtk+array/Proteome+Profiler+Human+Phospho-RTK+Array+Kit/pm41991671-211-6-16
    Average 96 stars, based on 358 article reviews
    proteome profiler human phospho rtk array kit - by Bioz Stars, 2026-09
    96/100 stars

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    Related Articles

    Generated:

    Article Title: P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice
    Article Snippet: The prognostic discrepancy between localized melanoma and metastatic disease demands a better understanding of melanoma progression.. The role of E-cadherin and N-cadherin in melanoma has been widely studied; however, the function of P-cadherin remains to be elucidated.. We wanted to assess the effects of P-cadherin overexpression in BLM melanoma cells with regard to xenograft growth, invasion, and survival of mice in our model to mimic micrometastatic spread.

    Article Title: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons
    Article Snippet: Phospho-RTK array (R&D systems) was performed using total brain protein extracts of P7 Bbs4 −/− and Bbs4 +/+ mice and in accordance with manufacture protocol.

    Article Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.
    Article Snippet: For each cell lysate, 300–500μg of total protein was analyzed using the phospho-RTK array (R&D Systems) and a phospho-kinase array (R&D Systems).

    Article Title: Targeting Insulin Receptor with a Novel Internalizing Aptamer
    Article Snippet: Cell lysates were incubated with the phospho-RTK array (R&D Systems, Minneapolis, MN) following manufacturer's instructions.

    Article Title: SHP2 inhibitor compositions and methods for treating cancer
    Article Snippet: NCI-H358 cells (Lung, KRASG12C) were grown into spheroids by seeding 5,000 cells/well in round bottom ultra-low attachment 96-well plates (Corning) in RPMI media (Gibco) supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin.

    Article Title: Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone
    Article Snippet: A human Phospho-RTK Array (R&D Systems) detecting phosphorylation status of 42 different RTKs was used to screen for bone-induced RTK activation in tumor cells.

    Article Title: Diverse Receptor Tyrosine Kinase Phosphorylation in Urine-Derived Tubular Epithelial Cells from Autosomal Dominant Polycystic Kidney Disease Patients.
    Article Snippet: Backgrounds: The clinical features of autosomal dominant polycystic kidney disease (ADPKD) differ among patients even if they have the same gene mutation in PKD1 or PKD2.. This suggests that there is diversity in the expression of other modifier genes or in the underlying molecular mechanisms of ADPKD, but these are not well understood.. Methods: We primarily cultured solute carrier family 12 member 3 (SLC12A3)-positive urine-derived distal tubular epithelial cells from 6 ADPKD patients and 4 healthy volunteers and established immortalized cell lines.

    Lysis:

    Article Title: P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice
    Article Snippet: The prognostic discrepancy between localized melanoma and metastatic disease demands a better understanding of melanoma progression.. The role of E-cadherin and N-cadherin in melanoma has been widely studied; however, the function of P-cadherin remains to be elucidated.. We wanted to assess the effects of P-cadherin overexpression in BLM melanoma cells with regard to xenograft growth, invasion, and survival of mice in our model to mimic micrometastatic spread.

    Article Title: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons
    Article Snippet: Phospho-RTK array (R&D systems) was performed using total brain protein extracts of P7 Bbs4 −/− and Bbs4 +/+ mice and in accordance with manufacture protocol.

    Article Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.
    Article Snippet: For each cell lysate, 300–500μg of total protein was analyzed using the phospho-RTK array (R&D Systems) and a phospho-kinase array (R&D Systems).

    Article Title: Targeting Insulin Receptor with a Novel Internalizing Aptamer
    Article Snippet: Cell lysates were incubated with the phospho-RTK array (R&D Systems, Minneapolis, MN) following manufacturer's instructions.

    Article Title: SHP2 inhibitor compositions and methods for treating cancer
    Article Snippet: NCI-H358 cells (Lung, KRASG12C) were grown into spheroids by seeding 5,000 cells/well in round bottom ultra-low attachment 96-well plates (Corning) in RPMI media (Gibco) supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin.

    Article Title: Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone
    Article Snippet: A human Phospho-RTK Array (R&D Systems) detecting phosphorylation status of 42 different RTKs was used to screen for bone-induced RTK activation in tumor cells.

    Article Title: Diverse Receptor Tyrosine Kinase Phosphorylation in Urine-Derived Tubular Epithelial Cells from Autosomal Dominant Polycystic Kidney Disease Patients.
    Article Snippet: Backgrounds: The clinical features of autosomal dominant polycystic kidney disease (ADPKD) differ among patients even if they have the same gene mutation in PKD1 or PKD2.. This suggests that there is diversity in the expression of other modifier genes or in the underlying molecular mechanisms of ADPKD, but these are not well understood.. Methods: We primarily cultured solute carrier family 12 member 3 (SLC12A3)-positive urine-derived distal tubular epithelial cells from 6 ADPKD patients and 4 healthy volunteers and established immortalized cell lines.

    Protease Inhibitor:

    Article Title: P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice
    Article Snippet: The prognostic discrepancy between localized melanoma and metastatic disease demands a better understanding of melanoma progression.. The role of E-cadherin and N-cadherin in melanoma has been widely studied; however, the function of P-cadherin remains to be elucidated.. We wanted to assess the effects of P-cadherin overexpression in BLM melanoma cells with regard to xenograft growth, invasion, and survival of mice in our model to mimic micrometastatic spread.

    Article Title: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons
    Article Snippet: Phospho-RTK array (R&D systems) was performed using total brain protein extracts of P7 Bbs4 −/− and Bbs4 +/+ mice and in accordance with manufacture protocol.

    Article Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.
    Article Snippet: For each cell lysate, 300–500μg of total protein was analyzed using the phospho-RTK array (R&D Systems) and a phospho-kinase array (R&D Systems).

    Article Title: Targeting Insulin Receptor with a Novel Internalizing Aptamer
    Article Snippet: Cell lysates were incubated with the phospho-RTK array (R&D Systems, Minneapolis, MN) following manufacturer's instructions.

    Article Title: SHP2 inhibitor compositions and methods for treating cancer
    Article Snippet: NCI-H358 cells (Lung, KRASG12C) were grown into spheroids by seeding 5,000 cells/well in round bottom ultra-low attachment 96-well plates (Corning) in RPMI media (Gibco) supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin.

    Article Title: Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone
    Article Snippet: A human Phospho-RTK Array (R&D Systems) detecting phosphorylation status of 42 different RTKs was used to screen for bone-induced RTK activation in tumor cells.

    Article Title: Diverse Receptor Tyrosine Kinase Phosphorylation in Urine-Derived Tubular Epithelial Cells from Autosomal Dominant Polycystic Kidney Disease Patients.
    Article Snippet: Backgrounds: The clinical features of autosomal dominant polycystic kidney disease (ADPKD) differ among patients even if they have the same gene mutation in PKD1 or PKD2.. This suggests that there is diversity in the expression of other modifier genes or in the underlying molecular mechanisms of ADPKD, but these are not well understood.. Methods: We primarily cultured solute carrier family 12 member 3 (SLC12A3)-positive urine-derived distal tubular epithelial cells from 6 ADPKD patients and 4 healthy volunteers and established immortalized cell lines.

    Incubation:

    Article Title: P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice
    Article Snippet: The prognostic discrepancy between localized melanoma and metastatic disease demands a better understanding of melanoma progression.. The role of E-cadherin and N-cadherin in melanoma has been widely studied; however, the function of P-cadherin remains to be elucidated.. We wanted to assess the effects of P-cadherin overexpression in BLM melanoma cells with regard to xenograft growth, invasion, and survival of mice in our model to mimic micrometastatic spread.

    Article Title: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons
    Article Snippet: Phospho-RTK array (R&D systems) was performed using total brain protein extracts of P7 Bbs4 −/− and Bbs4 +/+ mice and in accordance with manufacture protocol.

    Article Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.
    Article Snippet: For each cell lysate, 300–500μg of total protein was analyzed using the phospho-RTK array (R&D Systems) and a phospho-kinase array (R&D Systems).

    Article Title: Targeting Insulin Receptor with a Novel Internalizing Aptamer
    Article Snippet: Cell lysates were incubated with the phospho-RTK array (R&D Systems, Minneapolis, MN) following manufacturer's instructions.

    Article Title: SHP2 inhibitor compositions and methods for treating cancer
    Article Snippet: NCI-H358 cells (Lung, KRASG12C) were grown into spheroids by seeding 5,000 cells/well in round bottom ultra-low attachment 96-well plates (Corning) in RPMI media (Gibco) supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin.

    Article Title: Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone
    Article Snippet: A human Phospho-RTK Array (R&D Systems) detecting phosphorylation status of 42 different RTKs was used to screen for bone-induced RTK activation in tumor cells.

    Article Title: Diverse Receptor Tyrosine Kinase Phosphorylation in Urine-Derived Tubular Epithelial Cells from Autosomal Dominant Polycystic Kidney Disease Patients.
    Article Snippet: Backgrounds: The clinical features of autosomal dominant polycystic kidney disease (ADPKD) differ among patients even if they have the same gene mutation in PKD1 or PKD2.. This suggests that there is diversity in the expression of other modifier genes or in the underlying molecular mechanisms of ADPKD, but these are not well understood.. Methods: We primarily cultured solute carrier family 12 member 3 (SLC12A3)-positive urine-derived distal tubular epithelial cells from 6 ADPKD patients and 4 healthy volunteers and established immortalized cell lines.

    Western Blot:

    Article Title: P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice
    Article Snippet: The prognostic discrepancy between localized melanoma and metastatic disease demands a better understanding of melanoma progression.. The role of E-cadherin and N-cadherin in melanoma has been widely studied; however, the function of P-cadherin remains to be elucidated.. We wanted to assess the effects of P-cadherin overexpression in BLM melanoma cells with regard to xenograft growth, invasion, and survival of mice in our model to mimic micrometastatic spread.

    Article Title: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons
    Article Snippet: Phospho-RTK array (R&D systems) was performed using total brain protein extracts of P7 Bbs4 −/− and Bbs4 +/+ mice and in accordance with manufacture protocol.

    Article Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.
    Article Snippet: For each cell lysate, 300–500μg of total protein was analyzed using the phospho-RTK array (R&D Systems) and a phospho-kinase array (R&D Systems).

    Article Title: Targeting Insulin Receptor with a Novel Internalizing Aptamer
    Article Snippet: Cell lysates were incubated with the phospho-RTK array (R&D Systems, Minneapolis, MN) following manufacturer's instructions.

    Article Title: SHP2 inhibitor compositions and methods for treating cancer
    Article Snippet: NCI-H358 cells (Lung, KRASG12C) were grown into spheroids by seeding 5,000 cells/well in round bottom ultra-low attachment 96-well plates (Corning) in RPMI media (Gibco) supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin.

    Article Title: Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone
    Article Snippet: A human Phospho-RTK Array (R&D Systems) detecting phosphorylation status of 42 different RTKs was used to screen for bone-induced RTK activation in tumor cells.

    Article Title: Diverse Receptor Tyrosine Kinase Phosphorylation in Urine-Derived Tubular Epithelial Cells from Autosomal Dominant Polycystic Kidney Disease Patients.
    Article Snippet: Backgrounds: The clinical features of autosomal dominant polycystic kidney disease (ADPKD) differ among patients even if they have the same gene mutation in PKD1 or PKD2.. This suggests that there is diversity in the expression of other modifier genes or in the underlying molecular mechanisms of ADPKD, but these are not well understood.. Methods: We primarily cultured solute carrier family 12 member 3 (SLC12A3)-positive urine-derived distal tubular epithelial cells from 6 ADPKD patients and 4 healthy volunteers and established immortalized cell lines.

    Activation Assay:

    Article Title: P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice
    Article Snippet: The prognostic discrepancy between localized melanoma and metastatic disease demands a better understanding of melanoma progression.. The role of E-cadherin and N-cadherin in melanoma has been widely studied; however, the function of P-cadherin remains to be elucidated.. We wanted to assess the effects of P-cadherin overexpression in BLM melanoma cells with regard to xenograft growth, invasion, and survival of mice in our model to mimic micrometastatic spread.

    Article Title: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons
    Article Snippet: Phospho-RTK array (R&D systems) was performed using total brain protein extracts of P7 Bbs4 −/− and Bbs4 +/+ mice and in accordance with manufacture protocol.

    Article Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.
    Article Snippet: For each cell lysate, 300–500μg of total protein was analyzed using the phospho-RTK array (R&D Systems) and a phospho-kinase array (R&D Systems).

    Article Title: Targeting Insulin Receptor with a Novel Internalizing Aptamer
    Article Snippet: Cell lysates were incubated with the phospho-RTK array (R&D Systems, Minneapolis, MN) following manufacturer's instructions.

    Article Title: SHP2 inhibitor compositions and methods for treating cancer
    Article Snippet: NCI-H358 cells (Lung, KRASG12C) were grown into spheroids by seeding 5,000 cells/well in round bottom ultra-low attachment 96-well plates (Corning) in RPMI media (Gibco) supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin.

    Article Title: Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone
    Article Snippet: A human Phospho-RTK Array (R&D Systems) detecting phosphorylation status of 42 different RTKs was used to screen for bone-induced RTK activation in tumor cells.

    Article Title: Diverse Receptor Tyrosine Kinase Phosphorylation in Urine-Derived Tubular Epithelial Cells from Autosomal Dominant Polycystic Kidney Disease Patients.
    Article Snippet: Backgrounds: The clinical features of autosomal dominant polycystic kidney disease (ADPKD) differ among patients even if they have the same gene mutation in PKD1 or PKD2.. This suggests that there is diversity in the expression of other modifier genes or in the underlying molecular mechanisms of ADPKD, but these are not well understood.. Methods: We primarily cultured solute carrier family 12 member 3 (SLC12A3)-positive urine-derived distal tubular epithelial cells from 6 ADPKD patients and 4 healthy volunteers and established immortalized cell lines.

    Expressing:

    Article Title: P-cadherin expression reduces melanoma growth, invasion, and responsiveness to growth factors in nude mice
    Article Snippet: The prognostic discrepancy between localized melanoma and metastatic disease demands a better understanding of melanoma progression.. The role of E-cadherin and N-cadherin in melanoma has been widely studied; however, the function of P-cadherin remains to be elucidated.. We wanted to assess the effects of P-cadherin overexpression in BLM melanoma cells with regard to xenograft growth, invasion, and survival of mice in our model to mimic micrometastatic spread.

    Article Title: Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons
    Article Snippet: Phospho-RTK array (R&D systems) was performed using total brain protein extracts of P7 Bbs4 −/− and Bbs4 +/+ mice and in accordance with manufacture protocol.

    Article Title: IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.
    Article Snippet: For each cell lysate, 300–500μg of total protein was analyzed using the phospho-RTK array (R&D Systems) and a phospho-kinase array (R&D Systems).

    Article Title: Targeting Insulin Receptor with a Novel Internalizing Aptamer
    Article Snippet: Cell lysates were incubated with the phospho-RTK array (R&D Systems, Minneapolis, MN) following manufacturer's instructions.

    Article Title: SHP2 inhibitor compositions and methods for treating cancer
    Article Snippet: NCI-H358 cells (Lung, KRASG12C) were grown into spheroids by seeding 5,000 cells/well in round bottom ultra-low attachment 96-well plates (Corning) in RPMI media (Gibco) supplemented with 10% fetal bovine serum and 1% penicillin/streptomycin.

    Article Title: Inhibition of the Insulin-Like Growth Factor-1 Receptor Enhances Effects of Simvastatin on Prostate Cancer Cells in Co-Culture with Bone
    Article Snippet: A human Phospho-RTK Array (R&D Systems) detecting phosphorylation status of 42 different RTKs was used to screen for bone-induced RTK activation in tumor cells.

    Article Title: Diverse Receptor Tyrosine Kinase Phosphorylation in Urine-Derived Tubular Epithelial Cells from Autosomal Dominant Polycystic Kidney Disease Patients.
    Article Snippet: Backgrounds: The clinical features of autosomal dominant polycystic kidney disease (ADPKD) differ among patients even if they have the same gene mutation in PKD1 or PKD2.. This suggests that there is diversity in the expression of other modifier genes or in the underlying molecular mechanisms of ADPKD, but these are not well understood.. Methods: We primarily cultured solute carrier family 12 member 3 (SLC12A3)-positive urine-derived distal tubular epithelial cells from 6 ADPKD patients and 4 healthy volunteers and established immortalized cell lines.



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    A) Si-Control and Si-HIWI2 661W cell lysates were added <t>to</t> <t>Phospho-RTK</t> arrays. Spots are in duplicate and each pair corresponds to a specific Phospho-RTK. i) The top panel corresponds to control, and ii) while the bottom one corresponds to Si-HIWI2 cells. Phospho-Ephs corresponds to the doublet at E and F rows (marked with red box) showing decreased expression after knockdown of HIWI2. B) and C) Western blot analysis and D) and E) quantification of total and phospho form of EphA2 and EphB2 respectively upon knockdown of HIWI2 in 661W cells. The results were quantified and generated by Graph pad prism software. The students’ t-test was used for statistical analysis. Values are means ± SEM, n = 3. *p < 0.05 and **p < 0.01, ***p < 0.001 were considered statistically significant. Original blots for , and , are given in supplementary Fig.S2B, and C.
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    96
    R&D Systems tyrosine kinase activity
    NaJa cells differ in their response to drug treatment. A, Colony formation assay of NaJa cells treated with vemurafenib (V), encorafenib (E), and trametinib (T) at the indicated concentrations for 10 days. Shown is a representative result from three biological replicates. B–D, Quantification of the data shown in A . Data are presented as the mean ± SD and were normalized to the DMSO control ( n = 3). Statistical significance was calculated using one-way ANOVA and Dunnett multiple comparisons test. *, P < 0.05; **, P < 0.01; ****, P < 0.0001. <t>E,</t> <t>Phospho-RTK</t> array of NaJa cells treated with 1 μmol/L vemurafenib (Vem), 0.5 μmol/L encorafenib (Enco), or 50 nmol/L trametinib (Tram) for 5 days. Shown are the log 2 FCs of treated cells versus DMSO control. Array membranes and cell line specific heatmaps are displayed in Supplementary Fig. S7. F, Western blot showing the effect of a 5-day treatment of the NaJa cells on various signaling pathways. G, Western blot and quantification of HER2 and HER3 ( n = 4). Basal EGFR expression was quantified based on data in ( F ), and five additional biological replicates normalized to the internal loading control. Data are presented as the mean ± SD and were normalized to NaJa-F for comparison. Statistical significance was calculated using one-way ANOVA and Tukey multiple comparisons test. *, P < 0.05; **, P < 0.01; ****, P < 0.0001. H, Bulk RNA-seq of NaJa cells treated with 0.5 μmol/L encorafenib for 1 day or 5 days showing upregulation (red) or downregulation (blue) of ERK target genes and the adjusted P value (bubble size).
    Tyrosine Kinase Activity, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    proteome profiler human p rtk array kit  (R&D Systems)
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    R&D Systems proteome profiler human p rtk array kit
    NaJa cells differ in their response to drug treatment. A, Colony formation assay of NaJa cells treated with vemurafenib (V), encorafenib (E), and trametinib (T) at the indicated concentrations for 10 days. Shown is a representative result from three biological replicates. B–D, Quantification of the data shown in A . Data are presented as the mean ± SD and were normalized to the DMSO control ( n = 3). Statistical significance was calculated using one-way ANOVA and Dunnett multiple comparisons test. *, P < 0.05; **, P < 0.01; ****, P < 0.0001. <t>E,</t> <t>Phospho-RTK</t> array of NaJa cells treated with 1 μmol/L vemurafenib (Vem), 0.5 μmol/L encorafenib (Enco), or 50 nmol/L trametinib (Tram) for 5 days. Shown are the log 2 FCs of treated cells versus DMSO control. Array membranes and cell line specific heatmaps are displayed in Supplementary Fig. S7. F, Western blot showing the effect of a 5-day treatment of the NaJa cells on various signaling pathways. G, Western blot and quantification of HER2 and HER3 ( n = 4). Basal EGFR expression was quantified based on data in ( F ), and five additional biological replicates normalized to the internal loading control. Data are presented as the mean ± SD and were normalized to NaJa-F for comparison. Statistical significance was calculated using one-way ANOVA and Tukey multiple comparisons test. *, P < 0.05; **, P < 0.01; ****, P < 0.0001. H, Bulk RNA-seq of NaJa cells treated with 0.5 μmol/L encorafenib for 1 day or 5 days showing upregulation (red) or downregulation (blue) of ERK target genes and the adjusted P value (bubble size).
    Proteome Profiler Human P Rtk Array Kit, supplied by R&D Systems, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    Image Search Results


    A) Si-Control and Si-HIWI2 661W cell lysates were added to Phospho-RTK arrays. Spots are in duplicate and each pair corresponds to a specific Phospho-RTK. i) The top panel corresponds to control, and ii) while the bottom one corresponds to Si-HIWI2 cells. Phospho-Ephs corresponds to the doublet at E and F rows (marked with red box) showing decreased expression after knockdown of HIWI2. B) and C) Western blot analysis and D) and E) quantification of total and phospho form of EphA2 and EphB2 respectively upon knockdown of HIWI2 in 661W cells. The results were quantified and generated by Graph pad prism software. The students’ t-test was used for statistical analysis. Values are means ± SEM, n = 3. *p < 0.05 and **p < 0.01, ***p < 0.001 were considered statistically significant. Original blots for , and , are given in supplementary Fig.S2B, and C.

    Journal: bioRxiv

    Article Title: HIWI2 Influences Endosomal Trafficking and Eph Receptor Signaling in Photoreceptor Cells

    doi: 10.64898/2026.03.09.710476

    Figure Lengend Snippet: A) Si-Control and Si-HIWI2 661W cell lysates were added to Phospho-RTK arrays. Spots are in duplicate and each pair corresponds to a specific Phospho-RTK. i) The top panel corresponds to control, and ii) while the bottom one corresponds to Si-HIWI2 cells. Phospho-Ephs corresponds to the doublet at E and F rows (marked with red box) showing decreased expression after knockdown of HIWI2. B) and C) Western blot analysis and D) and E) quantification of total and phospho form of EphA2 and EphB2 respectively upon knockdown of HIWI2 in 661W cells. The results were quantified and generated by Graph pad prism software. The students’ t-test was used for statistical analysis. Values are means ± SEM, n = 3. *p < 0.05 and **p < 0.01, ***p < 0.001 were considered statistically significant. Original blots for , and , are given in supplementary Fig.S2B, and C.

    Article Snippet: Proteins that were altered after HIWI2 silencing were screened using the Phospho-RTK array kit (ARY001B, CST).

    Techniques: Control, Expressing, Knockdown, Western Blot, Generated, Software

    STAT3 is required for survival of melanoma cells treated with active RAS(ON) inhibitors. (A) Signaling responses to RAS(ON) inhibition in isogenic MeWo cells expressing WT, Q61R, Q61K, or Q61L NRAS. Bubble plot summarizing Western blot–derived signaling changes after 8-hour treatment with the indicated inhibitors. Band intensities were quantified by densitometry, normalized to vehicle controls (set to 100%), and represented as bubble size. Cells were treated with dose ranges appropriate for each inhibitor class: sotorasib and adagrasib (0.1, 1, 10 μM); ADT-007, BI-2865, RMC-6236, and RMC-7977 (0.01, 0.1, 1, 10 μM). (B) Western blot analysis of phospho-STAT3 (Tyr705) in MeWo isogenic cells treated with 1 μM RMC-6236 or RMC-7977 for 0, 12, or 24 hours. (C) Apoptosis followed by STAT3 knockdown combined with RAS(ON) inhibition. (i) Representative Annexin V–FITC/PI density plot of MeWo NRAS WT , NRAS Q61R , NRAS Q61K , and NRAS Q61L cells treated for 48 hours with 1 μM RMC-6236, 1 μM RMC-7977, or DMSO. Red gate denotes apoptotic cells (Annexin VL). (ii) Quantification of total apoptotic cells. Data are presented as mean ± SD (n = 3). Statistical significance was assessed using Two-way ANOVA with Sidak’s multiple-comparisons test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). (D) Western blot of MYC, p-STAT3, and cleaved PARP following siSTAT3 combined with 24-hour treatment with 1 μM RMC-6236 or RMC-7977. From (A) to (D), data were confirmed with independent experiments. (E) Receptor Tyrosine Kinase activation following RAS(ON) inhibitor treatment. (i) Representative phospho-RTK array from NRAS Q61R MeWo cells treated with 1 μM RMC-6236 or vehicle for 18 hours. (ii) Quantification of significantly upregulated RTKs. Data are mean ± SD. Statistical significance was determined by Two-way ANOVA with Sidak’s multiple-comparisons test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).

    Journal: bioRxiv

    Article Title: Mutation-Resolved Drug Sensitivity Atlas Reveals Broad RAS(ON) Inhibitor Vulnerabilities and a STAT3 Co-Dependency in NRAS-Mutant Melanoma

    doi: 10.64898/2026.02.18.706707

    Figure Lengend Snippet: STAT3 is required for survival of melanoma cells treated with active RAS(ON) inhibitors. (A) Signaling responses to RAS(ON) inhibition in isogenic MeWo cells expressing WT, Q61R, Q61K, or Q61L NRAS. Bubble plot summarizing Western blot–derived signaling changes after 8-hour treatment with the indicated inhibitors. Band intensities were quantified by densitometry, normalized to vehicle controls (set to 100%), and represented as bubble size. Cells were treated with dose ranges appropriate for each inhibitor class: sotorasib and adagrasib (0.1, 1, 10 μM); ADT-007, BI-2865, RMC-6236, and RMC-7977 (0.01, 0.1, 1, 10 μM). (B) Western blot analysis of phospho-STAT3 (Tyr705) in MeWo isogenic cells treated with 1 μM RMC-6236 or RMC-7977 for 0, 12, or 24 hours. (C) Apoptosis followed by STAT3 knockdown combined with RAS(ON) inhibition. (i) Representative Annexin V–FITC/PI density plot of MeWo NRAS WT , NRAS Q61R , NRAS Q61K , and NRAS Q61L cells treated for 48 hours with 1 μM RMC-6236, 1 μM RMC-7977, or DMSO. Red gate denotes apoptotic cells (Annexin VL). (ii) Quantification of total apoptotic cells. Data are presented as mean ± SD (n = 3). Statistical significance was assessed using Two-way ANOVA with Sidak’s multiple-comparisons test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001). (D) Western blot of MYC, p-STAT3, and cleaved PARP following siSTAT3 combined with 24-hour treatment with 1 μM RMC-6236 or RMC-7977. From (A) to (D), data were confirmed with independent experiments. (E) Receptor Tyrosine Kinase activation following RAS(ON) inhibitor treatment. (i) Representative phospho-RTK array from NRAS Q61R MeWo cells treated with 1 μM RMC-6236 or vehicle for 18 hours. (ii) Quantification of significantly upregulated RTKs. Data are mean ± SD. Statistical significance was determined by Two-way ANOVA with Sidak’s multiple-comparisons test (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).

    Article Snippet: RTK activation was evaluated using the Proteome ProfilerTM Human Phospho-RTK Array Kit (R&D Systems, Cat. No. ARY001B).

    Techniques: Inhibition, Expressing, Western Blot, Derivative Assay, Knockdown, Activation Assay

    NaJa cells differ in their response to drug treatment. A, Colony formation assay of NaJa cells treated with vemurafenib (V), encorafenib (E), and trametinib (T) at the indicated concentrations for 10 days. Shown is a representative result from three biological replicates. B–D, Quantification of the data shown in A . Data are presented as the mean ± SD and were normalized to the DMSO control ( n = 3). Statistical significance was calculated using one-way ANOVA and Dunnett multiple comparisons test. *, P < 0.05; **, P < 0.01; ****, P < 0.0001. E, Phospho-RTK array of NaJa cells treated with 1 μmol/L vemurafenib (Vem), 0.5 μmol/L encorafenib (Enco), or 50 nmol/L trametinib (Tram) for 5 days. Shown are the log 2 FCs of treated cells versus DMSO control. Array membranes and cell line specific heatmaps are displayed in Supplementary Fig. S7. F, Western blot showing the effect of a 5-day treatment of the NaJa cells on various signaling pathways. G, Western blot and quantification of HER2 and HER3 ( n = 4). Basal EGFR expression was quantified based on data in ( F ), and five additional biological replicates normalized to the internal loading control. Data are presented as the mean ± SD and were normalized to NaJa-F for comparison. Statistical significance was calculated using one-way ANOVA and Tukey multiple comparisons test. *, P < 0.05; **, P < 0.01; ****, P < 0.0001. H, Bulk RNA-seq of NaJa cells treated with 0.5 μmol/L encorafenib for 1 day or 5 days showing upregulation (red) or downregulation (blue) of ERK target genes and the adjusted P value (bubble size).

    Journal: Cancer Research Communications

    Article Title: Novel Syngeneic Cell Lines for Studying High-Risk BRAF V600E -Driven Colorectal Cancer In Vivo

    doi: 10.1158/2767-9764.CRC-25-0599

    Figure Lengend Snippet: NaJa cells differ in their response to drug treatment. A, Colony formation assay of NaJa cells treated with vemurafenib (V), encorafenib (E), and trametinib (T) at the indicated concentrations for 10 days. Shown is a representative result from three biological replicates. B–D, Quantification of the data shown in A . Data are presented as the mean ± SD and were normalized to the DMSO control ( n = 3). Statistical significance was calculated using one-way ANOVA and Dunnett multiple comparisons test. *, P < 0.05; **, P < 0.01; ****, P < 0.0001. E, Phospho-RTK array of NaJa cells treated with 1 μmol/L vemurafenib (Vem), 0.5 μmol/L encorafenib (Enco), or 50 nmol/L trametinib (Tram) for 5 days. Shown are the log 2 FCs of treated cells versus DMSO control. Array membranes and cell line specific heatmaps are displayed in Supplementary Fig. S7. F, Western blot showing the effect of a 5-day treatment of the NaJa cells on various signaling pathways. G, Western blot and quantification of HER2 and HER3 ( n = 4). Basal EGFR expression was quantified based on data in ( F ), and five additional biological replicates normalized to the internal loading control. Data are presented as the mean ± SD and were normalized to NaJa-F for comparison. Statistical significance was calculated using one-way ANOVA and Tukey multiple comparisons test. *, P < 0.05; **, P < 0.01; ****, P < 0.0001. H, Bulk RNA-seq of NaJa cells treated with 0.5 μmol/L encorafenib for 1 day or 5 days showing upregulation (red) or downregulation (blue) of ERK target genes and the adjusted P value (bubble size).

    Article Snippet: From each sample, the recommended amounts (250 μg) of protein were used for the Proteome Profiler Mouse Phospho-RTK Array Kit (ARY0141, R&D systems).

    Techniques: Colony Assay, Control, Western Blot, Protein-Protein interactions, Expressing, Comparison, RNA Sequencing